Protein Information

Name CXCL8
Synonyms 3 10C; AMCF I; CXC chemokine ligand 8; CXCL 8; CXCL8; Emoctakin; GCP 1; GCP1…

Compound Information

Name sulfoxide
CAS 5-[2-(octylsulfinyl)propyl]-1,3-benzodioxole

Reference List

PubMed Abstract RScore(About this table)
18506912 Maggiora M, Rossi MA: Changes in IL-8 release and intracellular content in DMSO-differentiated HL-60 cells after treatment with 4-hydroxynonenal. Cell Biochem Funct. 2008 Sep-Oct;26(5):566-70.

4(0,0,0,4) Details
19966493 Saegusa S, Totsuka M, Kaminogawa S, Hosoi T: Saccharomyces cerevisiae and Candida albicans stimulate cytokine secretion from human neutrophil-like HL-60 cells differentiated with retinoic acid or dimethylsulfoxide. Biosci Biotechnol Biochem. 2009 Dec;73(12):2600-8. Epub 2009 Dec 7.


Intact and heat-killed S. cerevisiae enhanced secretion of interleukin (IL)-1beta, IL-6, IL-8, IL-12, IL-18, MCP-1/CCL2 and TNF-alpha from retinoic acid-treated HL-60 cells, accompanied by alterations in mRNA expression of the cytokines.
2(0,0,0,2) Details
19661176 Cervantes-Sandoval I, Serrano-Luna Jde J, Meza-Cervantez P, Arroyo R, Tsutsumi V, Shibayama M: Naegleria fowleri induces MUC5AC and pro-inflammatory cytokines in human epithelial cells via ROS production and EGFR activation. Microbiology. 2009 Nov;155(Pt 11):3739-47. Epub 2009 Aug 6.


Furthermore, the expression of MUC5AC, IL-8 and IL-1 beta was inhibited in the presence of the ROS scavenger DMSO.
2(0,0,0,2) Details
19551541 Akkok CA, Liseth K, Hervig T, Ryningen A, Bruserud O, Ersvaer E: Use of different DMSO concentrations for cryopreservation of autologous peripheral blood stem cell grafts does not have any major impact on levels of leukocyte- and platelet-derived soluble mediators. Cytotherapy. 2009 Jun 23:1-12.


Low or undetectable levels of leukocyte-derived intereukin (IL)-6 and tumor necrosis factor (TNF)-alpha and CXCL8, high levels of platelet-derived CCL5 and CXCL4, and high levels of monocyte-derived soluble CD14 were measured independent of the DMSO concentration, except for slightly increased CXCL8 and decreased CXCL4 levels with 2% DMSO.
1(0,0,0,1) Details
19878061 Akkok CA, Liseth K, Hervig T, Ryningen A, Bruserud O, Ersvaer E: Use of different DMSO concentrations for cryopreservation of autologous peripheral blood stem cell grafts does not have any major impact on levels of leukocyte- and platelet-derived soluble mediators. Cytotherapy. 2009;11(6):749-60.


Low or undetectable levels of leukocyte-derived interleukin (IL)-6 and tumor necrosis factor (TNF)-alpha and CXCL8, high levels of platelet-derived CCL5 and CXCL4, and high levels of monocyte-derived soluble CD14 were measured independent of the DMSO concentration, except for slightly increased CXCL8 and decreased CXCL4 levels with 2% DMSO.
1(0,0,0,1) Details
18205049 Liu Y, Sai J, Richmond A, Wikswo JP: Microfluidic switching system for analyzing chemotaxis responses of wortmannin-inhibited HL-60 cells. Biomed Microdevices. 2008 Aug;10(4):499-507.


The studies quantify the chemotaxis gradient and the effects of a change in the direction of a CXCL-8 gradient on cell migration.
1(0,0,0,1) Details
20084046 Omori K, Todorov I, Shintaku J, Rawson J, Al-Abdullah IH, Higgins LS, Medicherla S, Kandeel F, Mullen Y: P38alpha-Selective Mitogen-Activated Protein Kinase Inhibitor for Improvement of Cultured Human Islet Recovery. Pancreas. 2010 Jan 13.


Interleukin 6 mRNA expression in cultured islets, as well as IL-6, IL-8, and granulocyte-macrophage colony-stimulating factor released into the medium, was significantly reduced by adding SD-282.
1(0,0,0,1) Details