Protein Information

Name carbonic anhydrase
Synonyms CA IX; CA1; Carbonic anhydrase I; CA2; CAII; Carbonic anhydrase II; Carbonic dehydratase; Carbonic anhydrase III…

Compound Information

Name sulfoxide
CAS 5-[2-(octylsulfinyl)propyl]-1,3-benzodioxole

Reference List

PubMed Abstract RScore(About this table)
18970531 Soliman EM, Saleh MB, Ahmed SA: Alumina modified by dimethyl sulfoxide as a new selective solid phase extractor for separation and preconcentration of inorganic mercury (II). Talanta. 2006 Mar 15;69(1):55-60. Epub 2005 Dec 13.

Dimethyl sulfoxide (DMSO) was simply immobilized to neutral alumina via quite strong hydrogen bonding between sulfoxide oxygen and surface alumina hydroxo groups.
Hg (II) uptake was 1.90 mmol g (-1)(distribution coefficient log K (d)=5.658) at pH 1.0 or 2.0, 1.68 mmol g (-1) (log K (d)=4.067) at pH 3.0 or 4.0 while the metal ions Ca (II), Fe (III), Co (II), Ni (II), Cu (II), Zn (II), Cd (II) and Pb (II) showed low values 0.513-0.118 mmol g (-1) (log K (d)<3.0) in the pH range 4.0-7.0.
1(0,0,0,1) Details
18957172 Crumb W, Benyamina A, Arbus C, Thomas GP, Garay RP, Hameg A: Cyamemazine metabolites: effects on human cardiac ion channels in-vitro and on the QTc interval in guinea pigs. J Pharm Pharmacol. 2008 Nov;60(11):1507-13.

Monodesmethyl cyamemazine and cyamemazine sulfoxide, the two main metabolites of the antipsychotic and anxiolytic phenothiazine cyamemazine, were investigated for their effects on the human ether-a-go-go related gene (hERG) channel expressed in HEK 293 cells and on native I (Na), I (Ca), I (to), I (sus) or I (K1) of human atrial myocytes.
31(0,1,1,1) Details
17977608 Akbari E, Motamedi F, Naghdi N, Noorbakhshnia M: The effect of antagonization of orexin 1 receptors in CA1 and dentate gyrus regions on memory processing in passive avoidance task. Behav Brain Res. 2008 Feb 11;187(1):172-7. Epub 2007 Sep 20.

3(0,0,0,3) Details
17504133 Dogne JM, Thiry A, Pratico D, Masereel B, Supuran CT: Dual carbonic anhydrase--cyclooxygenase-2 inhibitors. . Curr Top Med Chem. 2007;7(9):885-91.

3(0,0,0,3) Details
19144965 Grover LM, Kim E, Cooke JD, Holmes WR: LTP in hippocampal area CA1 is induced by burst stimulation over a broad frequency range centered around delta. Learn Mem. 2009 Jan 7;16(1):69-81. Print 2009.

3(0,0,0,3) Details
19030623 Taran O, Medrano F, Yatsimirsky AK: Rapid hydrolysis of model phosphate diesters by alkaline-earth cations in aqueous DMSO: speciation and kinetics. Dalton Trans. 2008 Dec 14;(46):6609-18. Epub 2008 Oct 9.


Kinetics of the cleavage of two phosphate diesters, bis (4-nitrophenyl) phosphate and 2-hydroxypropyl 4-nitrophenyl phosphate and a triester, 4-nitrophenyl diphenyl phosphate, in the presence of Mg (II), Ca (II) and Sr (II) were studied in 90% vol.
2(0,0,0,2) Details
19873921 Miao T, Jiang TS, Dong YH, Jiang NC: [Effects of auricular acupuncture on the memory and the expression of ChAT and GFAP in model rats with Alzheimer's disease]. Zhongguo Zhen Jiu. 2009 Oct;29(10):827-32.


The model rats with AD were established by multiple injections with Okadaic Acid into the CA1 region of hippocampus.
2(0,0,0,2) Details
18203987 Ebanks SC, Grosell M: Fluid and osmolyte recovery in the common pond snail Lymnaea stagnalis following full-body withdrawal. J Exp Biol. 2008 Feb;211(Pt 3):327-36.


Recovery uptake was significantly reduced by amiloride, ethylisopropylamiloride, bafilomycin and ethoxzolamide indicating dependency upon Na (+)/H (+) exchange, H (+) pump activity and H (+) from carbonic anhydrase-catalyzed CO (2) hydration.
1(0,0,0,1) Details
17600733 Easter A, Sharp TH, Valentin JP, Pollard CE: Pharmacological validation of a semi-automated in vitro hippocampal brain slice assay for assessment of seizure liability. J Pharmacol Toxicol Methods. 2007 Sep-Oct;56(2):223-33. Epub 2007 May 24.


Population spikes (PS) were evoked at 30 s intervals by electrical stimulation of the Schaffer collateral pathway and were recorded using extracellular electrodes positioned in the CA1 cell body layer.
1(0,0,0,1) Details
19096138 Di Giorgio AM, Hou Y, Zhao X, Zhang B, Lyeth BG, Russell MJ: Dimethyl sulfoxide provides neuroprotection in a traumatic brain injury model. Restor Neurol Neurosci. 2008;26(6):501-7.


Degenerating neurons in the CA2-3 sector of the dorsal hippocampus were quantified in 10 sections spaced 300 microm apart in each rat.
1(0,0,0,1) Details