Protein Information

Name catalase
Synonyms CAT; Catalase; Erythrocyte derived growth promoting factor; Carnitine O acetyltransferase; Carnitine acetylase; Carnitine acetyltransferase; CAT; Catalases…

Compound Information

Name sulfoxide
CAS 5-[2-(octylsulfinyl)propyl]-1,3-benzodioxole

Reference List

PubMed Abstract RScore(About this table)
18790186 Shen CY, Lee JF, Su CL, Wang D, Chen CF: Hypoxia and reoxygenation of the lung tissues induced mRNA expressions of superoxide dismutase and catalase and interventions from different antioxidants. Transplant Proc. 2008 Sep;40(7):2182-4.

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20171027 Lahnsteiner F, Mansour N, Plaetzer K: Antioxidant systems of brown trout (Salmo trutta f. fario) semen. Anim Reprod Sci. 2010 Jun;119(3-4):314-21. Epub 2010 Feb 1.


In seminal plasma and spermatozoa the enzymes catalase, glutathione reductase, methionine sulfoxide reductase, peroxidase, and superoxide dismutase and the metabolites ascorbic acid, glutathione, methionine, tocopherol, and uric acid were detected.
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19900747 Silveira PC, Victor EG, Schefer D, Silva LA, Streck EL, Paula MM, Pinho RA: Effects of therapeutic pulsed ultrasound and dimethylsulfoxide (DMSO) phonophoresis on parameters of oxidative stress in traumatized muscle. Ultrasound Med Biol. 2010 Jan;36(1):44-50. Epub .


Superoxide anion, TBARS, protein carbonyls, superoxide dismutase (SOD) and catalase (CAT) activity was used as indicators of stress oxidative.
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18699726 Johnston PA, Soares KM, Shinde SN, Foster CA, Shun TY, Takyi HK, Wipf P, Lazo JS: Development of a 384-well colorimetric assay to quantify hydrogen peroxide generated by the redox cycling of compounds in the presence of reducing agents. Assay Drug Dev Technol. 2008 Aug;6(4):505-18.


The generation of H (2) O (2) was dependent on the concentration of both the compound and DTT and was abolished by catalase.
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19114548 Wu H, Soler-Garcia AA, Jerse AE: A strain-specific catalase mutation and mutation of the metal-binding transporter gene mntC attenuate Neisseria gonorrhoeae in vivo but not by increasing susceptibility to oxidative killing by phagocytes. Infect Immun. 2009 Mar;77(3):1091-102. Epub 2008 Dec 29.


Here we showed that a gonococcal catalase (kat) mutant in strain MS11 was more sensitive to H (2) O (2) than mutants in cytochrome c peroxidase (ccp), methionine sulfoxide reductase (msrA), or the metal-binding protein (mntC) of the MntABC transporter. kat ccp and kat ccp mntC mutants were significantly more sensitive to H (2) O (2) than mutants in any single factor.
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17366568 Badisa VL, Latinwo LM, Odewumi CO, Ikediobi CO, Badisa RB, Ayuk-Takem LT, Nwoga J, West J: Mechanism of DNA damage by cadmium and interplay of antioxidant enzymes and agents. Environ Toxicol. 2007 Apr;22(2):144-51.


Of the two antioxidant enzymes (catalase and superoxide dismutase) studied, only catalase conferred significant (50-60%) protection.
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17624324 Lebedinsky AS, Cherkashina DV, Sukach AN, Volkova NA, Fuller BJ, Petrenko AY: Positive effects of cryopreserved adult or fetal liver cell transplants on hypercholesterolemia and hepatic antioxidant defenses in cholesterol-fed rabbits. Cryobiology. 2007 Aug;55(1):72-9. Epub 2007 Jun 8.


CFLC transplantation also normalized hepatic tissue antioxidant defenses, namely an increase in reduced glutathione content, and enzyme activities for catalase and glutathione reductase (all significantly higher at p <0.05 than in Sham transplants) by 4 weeks.
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17854709 O'Hara KA, Wu X, Patel D, Liang H, Yalowich JC, Chen N, Goodfellow V, Adedayo O, Dmitrienko GI, Hasinoff BB: Mechanism of the cytotoxicity of the diazoparaquinone antitumor antibiotic kinamycin F. Free Radic Biol Med. 2007 Oct 15;43(8):1132-44. Epub 2007 Jul 13.


The GSH-promoted DNA nicking induced by kinamycin F in vitro was attenuated by deferoxamine, dimethyl sulfoxide, and catalase, which indicated that DNA damage initiated by this agent occurred in an iron-, hydrogen-peroxide-, and hydroxyl-radical-dependent manner.
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18665441 Bernard Y, Melchior C, Tschirhart E, Bueb JL: Co-cultures of human coronary smooth muscle cells and dimethyl sulfoxide-differentiated HL60 cells upregulate ProMMP9 activity and promote mobility-modulation by reactive oxygen species. Inflammation. 2008 Oct;31(5):287-98.


The effects of superoxide dismutase (SOD) and catalase were also analyzed.
1(0,0,0,1) Details
19329172 Taylor MA, Guzman-Novoa E, Morfin N, Buhr MM: Improving viability of cryopreserved honey bee (Apis mellifera L.) sperm with selected diluents, cryoprotectants, and semen dilution ratios. Theriogenology. 2009 Jul 15;72(2):149-59. Epub 2009 Mar 28.


Semen collected at high dilution ratios, using a hypotonic antioxidant diluent containing catalase, in combination with dimethyl sulfoxide, provided higher postthaw sperm viability than that of all other combinations tested (68.3+/-5.4%; P <0.05).
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18273562 Mishra P, Kale RK, Kar A: Chemoprevention of mammary tumorigenesis and chemomodulation of the antioxidative enzymes and peroxidative damage in prepubertal Sprague Dawley rats by Biochanin A. Mol Cell Biochem. 2008 May;312(1-2):1-9. Epub 2008 Feb 14.


Spectrophotometric enzyme estimations revealed that the specific activities of antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione transferase (GST), DT-diaphorase (DTD), and reduced glutathione (GSH) levels were increased, whereas specific activities of lactate dehydrogenase (LDH) and lipid peroxidation (LPO) were decreased significantly, both in liver as well as in mammary gland, in animals treated with Biochanin A prepubertally.
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19224685 Zhang M, Zhu LJ, Jia ZY, Xiao Y, Ju L, Zhang X: [Chrysotile fibers induced apoptosis of human bronchial epithelial cells and effect of oxidation]. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2009 Jan;27(1):11-5.


Addition of free radical scavengers such as catalase, dimethyl sulfoxide and mannitol prevented the radical generation and gene expression.
1(0,0,0,1) Details
17943184 Schallreuter KU, Rubsam K, Gibbons NC, Maitland DJ, Chavan B, Zothner C, Rokos H, Wood JM: Methionine sulfoxide reductases A and B are deactivated by hydrogen peroxide (H2O2) in the epidermis of patients with vitiligo. J Invest Dermatol. 2008 Apr;128(4):808-15. Epub 2007 Oct 18.

Patients with the depigmentation disorder vitiligo have low catalase expression/activities and constantly accumulate 10 (-3) M hydrogen peroxide (H (2) O (2)) in their skin.
Such high concentrations of H (2) O (2) oxidize L-methionine residues in proteins and peptides to (R and S)-methionine sulfoxide diasteriomers.
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18005266 Ratthe C, Girard D: Investigation of the interleukin (IL)-4/IL-4 receptor system in promyelocytic leukaemia PLB-985 cells during differentiation toward neutrophil-like phenotype: mechanism involved in IL-4-induced SOCS3 protein expression. Br J Haematol. 2008 Jan;140(1):59-70. Epub 2007 Nov 12.


Utilization of catalase, cycloheximide and genistein inhibitors showed that IL-4 induced SOCS3 by a mechanism dependent on a complete NADPH oxidase complex, protein synthesis and tyrosine phosphorylation, but independent of production of reactive oxygen species.
1(0,0,0,1) Details
19237503 Wood JM, Decker H, Hartmann H, Chavan B, Rokos H, Spencer JD, Hasse S, Thornton MJ, Shalbaf M, Paus R, Schallreuter KU: Senile hair graying: H2O2-mediated oxidative stress affects human hair color by blunting methionine sulfoxide repair. FASEB J. 2009 Jul;23(7):2065-75. Epub 2009 Feb 23.


Moreover, we demonstrate almost absent catalase and methionine sulfoxide reductase A and B protein expression via immunofluorescence and Western blot in association with a functional loss of methionine sulfoxide (Met-S=O) repair in the entire gray hair follicle.
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17391968 Boojar MM, Shockravi A: On the cytotoxicity and status of oxidative stress of two novel synthesized tri-aza macrocyclic diamides as studied in the V79 cell lines. Bioorg Med Chem. 2007 May 15;15(10):3437-44. Epub 2007 Mar 12.

In this study, we comparatively evaluated cytotoxicity effects of tri-aza dibenzo sulfoxide (TSD) and dibenzo sulfide (TTS) macrocyclic diamides in a range of doses (0.5-8mM) and the role of oxidative stress in V79 cell culture.
We assessed the effects of these substances on ROS level, cellular viability, apoptosis events, activity of antioxidant enzymes including superoxide dismutase (SOD), glutathione peroxidase (GPX), catalase (CAT), and on some macromolecules' oxidative damage end-products: malondialdehyde (MDA), dityrosine, and 8-hydroxy-deoxyguanosine (8-OH-dG) that were assessed by spectrometry and HPLC methods.
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19665240 Wu TM, Hsu YT, Sung MS, Hsu YT, Lee TM: Expression of genes involved in redox homeostasis and antioxidant defense in a marine macroalga Ulva fasciata by excess copper. Aquat Toxicol. 2009 Oct 4;94(4):275-85. Epub 2009 Jul 19.


Phycologia 47, 346-360] were cloned and their expression was compared to superoxide dismutase (UfMnsod and UfFesod), ascorbate peroxidase (UfApx), glutathione reductase (UfGr), and catalase (UfCat).
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19945446 Bergandi L, Aina V, Garetto S, Malavasi G, Aldieri E, Laurenti E, Matera L, Morterra C, Ghigo D: Fluoride-containing bioactive glasses inhibit pentose phosphate oxidative pathway and glucose 6-phosphate dehydrogenase activity in human osteoblasts. Chem Biol Interact. 2010 Feb 12;183(3):405-15. Epub 2009 Nov 27.


The presence of fluoride-containing glasses and NaF caused also the generation of reactive oxygen species, which was prevented by superoxide dismutase and catalase.
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18682396 Schwarzer C, Fu Z, Fischer H, Machen TE: Redox-independent activation of NF-kappaB by Pseudomonas aeruginosa pyocyanin in a cystic fibrosis airway epithelial cell line. J Biol Chem. 2008 Oct 3;283(40):27144-53. Epub 2008 Aug 5.


Catalase also reversed the inhibitory effects of H (2) O (2) on NF-kappaB.
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18513221 Morel M, Kohler A, Martin F, Gelhaye E, Rouhier N: Comparison of the thiol-dependent antioxidant systems in the ectomycorrhizal Laccaria bicolor and the saprotrophic Phanerochaete chrysosporium. New Phytol. 2008;180(2):391-407. Epub 2008 May 28.


Central to the antioxidant systems are superoxide dismutases, catalases and thiol-dependent peroxidases (Tpx).
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17438788 Alaghmand M, Blough NV: Source-dependent variation in hydroxyl radical production by airborne particulate matter. Environ Sci Technol. 2007 Apr 1;41(7):2364-70.


Hydroxyl radical formation was eliminated under anaerobic conditions and in the presence of catalase, indicating that 02 and H202 are required for its generation.
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19432210 Pauk VV, Nasibullin TR, Tuktarova IA, Zueva LP, Mustafina OE: [Antioxidant gene polymorphism and longevity] . Adv Gerontol. 2008;21(4):593-5.


On sample of 1534 ethnic Tatars catalase (CAT, -262C/T), glutathione peroxidase 1 (GPX1, L198P) and methionine sulfoxide reductase A (MSRA, -402C/T) gene polymorphisms in connection with lifespan were studied.
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17525399 Miller AA, Drummond GR, Mast AE, Schmidt HH, Sobey CG: Effect of gender on NADPH-oxidase activity, expression, and function in the cerebral circulation: role of estrogen. Stroke. 2007 Jul;38(7):2142-9. Epub 2007 May 24.


The hydrogen peroxide scavenger, catalase, abolished these NADPH-induced relaxations.
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17347324 Elfarra AA, Krause RJ: S-(1,2,2-trichlorovinyl)-L-cysteine sulfoxide, a reactive metabolite of S-(1,2,2-Trichlorovinyl)-L-cysteine formed in rat liver and kidney microsomes, is a potent nephrotoxicant. J Pharmacol Exp Ther. 2007 Jun;321(3):1095-101. Epub 2007 Mar 8.

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