| Name | FMO3 |
|---|---|
| Synonyms | Dimethylaniline monooxygenase [N oxide forming] 3; Dimethylaniline oxidase 3; FMO 3; FMO II; FMO form 2; FMO3; FMOII; Flavin containing monooxygenase 3… |
| Name | sulfoxide |
|---|---|
| CAS | 5-[2-(octylsulfinyl)propyl]-1,3-benzodioxole |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 18930712 | Krause RJ, Elfarra AA: Reduction of selenoxide to seleno- by endogenous thiols, or methimazole. Biochem Pharmacol. 2009 Jan 1;77(1):134-40. Epub 2008 Sep 27. Seleno- (SeMet) can be oxidized to selenoxide (MetSeO) by flavin-containing monooxygenase 3 (FMO3) and rat liver microsomes in the presence of |
1(0,0,0,1) | Details |
| 18681461 | Barshteyn N, Elfarra AA: Detection of multiple globin monoadducts and cross-links after in vitro exposure of rat erythrocytes to S-(1,2-dichlorovinyl)- sulfoxide and after in vivo treatment of rats with S-(1,2-dichlorovinyl)- sulfoxide. Chem Res Toxicol. 2008 Sep;21(9):1716-25. Epub 2008 Aug 6. S-(1,2-dichlorovinyl)- sulfoxide (DCVCS), a Michael acceptor produced by an FMO3-mediated oxidation of the trichloroethylene metabolite S-(1,2-dichlorovinyl)- (DCVC), is a more potent nephrotoxicant than DCVC. |
31(0,1,1,1) | Details |
| 17892265 | Barshteyn N, Elfarra AA: Formation of three N-acetyl- monoadducts and one diadduct by the reaction of S-(1,2-dichlorovinyl)- sulfoxide with N-acetyl- at physiological conditions: chemical mechanisms and toxicological implications. Chem Res Toxicol. 2007 Oct;20(10):1563-9. Epub 2007 Sep 25. Previously, our laboratory has shown that S-(1,2-dichlorovinyl)- sulfoxide (DCVCS), a Michael acceptor produced by a flavin-containing monooxygenase 3 (FMO3)-mediated oxidation of S-(1,2-dichlorovinyl)- (DCVC), is a more potent nephrotoxicant than DCVC. |
31(0,1,1,1) | Details |
| 19283698 | Hai X, Adams E, Hoogmartens J, Van Schepdael A: Enantioselective in-line and off-line CE methods for the kinetic study on cimetidine and its chiral metabolites with reference to flavin-containing monooxygenase genetic isoforms. Electrophoresis. 2009 Apr;30(7):1248-57. FMO1 produces more (-)-CSO-enantiomer, while FMO3 generates mainly (+)-CSO-enantiomer. |
2(0,0,0,2) | Details |
| 18930751 | Henderson MC, Siddens LK, Morre JT, Krueger SK, Williams DE: Metabolism of the anti-tuberculosis drug ethionamide by mouse and human FMO1, FMO2 and FMO3 and mouse and human lung microsomes. Toxicol Appl Pharmacol. 2008 Dec 15;233(3):420-7. Epub 2008 Oct 1. M. tuberculosis possesses a flavin monooxygenase (EtaA) that oxygenates ETA first to the sulfoxide and then to 2-ethyl-4-amidopyridine, presumably through a second oxygenation involving sulfinic acid. |
2(0,0,0,2) | Details |