| Name | FMO1 |
|---|---|
| Synonyms | Dimethylaniline monooxygenase 1; Dimethylaniline monooxygenase [N oxide forming] 1; Dimethylaniline oxidase 1; FMO 1; FMO1; Fetal hepatic flavin containing monooxygenase 1; Flavin containing monooxygenase 1; Dimethylaniline monooxygenase [N oxide forming] 1s… |
| Name | sulfoxide |
|---|---|
| CAS | 5-[2-(octylsulfinyl)propyl]-1,3-benzodioxole |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19429252 | Rodriguez-Fuentes G, Coburn C, Curras-Collazo M, Guillen G, Schlenk D: Effect of hyperosmotic conditions on flavin-containing monooxygenase activity, protein and mRNA expression in rat kidney. Toxicol Lett. 2009 Jun 1;187(2):115-8. Epub 2009 Feb 20. Methyl-p-tolyl sulfide oxidase showed a statistically significant increase in FMO activity, and a positive correlation was observed between plasma osmolarity and production of FMO1-derived (R)-methyl-p-tolyl sulfoxide (p <0.05, r=0.6736). |
84(1,1,1,4) | Details |
| 19283698 | Hai X, Adams E, Hoogmartens J, Van Schepdael A: Enantioselective in-line and off-line CE methods for the kinetic study on cimetidine and its chiral metabolites with reference to flavin-containing monooxygenase genetic isoforms. Electrophoresis. 2009 Apr;30(7):1248-57. FMO1 produces more (-)-CSO-enantiomer, while FMO3 generates mainly (+)-CSO-enantiomer. |
3(0,0,0,3) | Details |
| 18930751 | Henderson MC, Siddens LK, Morre JT, Krueger SK, Williams DE: Metabolism of the anti-tuberculosis drug ethionamide by mouse and human FMO1, FMO2 and FMO3 and mouse and human lung microsomes. Toxicol Appl Pharmacol. 2008 Dec 15;233(3):420-7. Epub 2008 Oct 1. M. tuberculosis possesses a flavin monooxygenase (EtaA) that oxygenates ETA first to the sulfoxide and then to 2-ethyl-4-amidopyridine, presumably through a second oxygenation involving sulfinic acid. |
1(0,0,0,1) | Details |