| Name | myeloperoxidase |
|---|---|
| Synonyms | 38 kDa MYELOPEROXIDASE; MPO; Myeloperoxidase; Myeloperoxidase precursor; Peroxidase (Myeloperoxidase); Myeloperoxidases; Myeloperoxidase precursors; Peroxidase (Myeloperoxidase)s |
| Name | sulfoxide |
|---|---|
| CAS | 5-[2-(octylsulfinyl)propyl]-1,3-benzodioxole |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19812385 | Chen J, Fu X, Wang Y, Ling M, McMullen B, Kulman J, Chung DW, Lopez JA: Oxidative modification of von Willebrand factor by neutrophil oxidants inhibits its cleavage by ADAMTS13. Blood. 2010 Jan 21;115(3):706-12. Epub 2009 Oct 7. HOCl is produced from peroxide and ions through the action of myeloperoxidase. Met (1606) was oxidized to the sulfoxide in a concentration-dependent manner, with complete oxidation at 75muM HOCl, whereas only a miniscule percentage of Tyr (1605) was converted to chlorotyrosine. |
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| 19321049 | Zhou JL, Li G, Hai Y, Guan L, Huang XL, Sun P: Protection of -releasing molecule against lung injury induced by limb ischemia-reperfusion. Chin J Traumatol. 2009 Apr;12(2):71-6. The lung tissue structure, polymorphonuclear neutrophil (PMN) count, wet-to-dry weight ratio (W/D), malondialdehyde (MDA) content, myeloperoxidase (MPO) activity, intercellular adhesion molecule-1 (ICAM-1) expression,IkBa degradation and nuclear factor (NF)-kB activity in the lungs were assessed. |
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| 20167109 | Galuppo M, Di Paola R, Mazzon E, Genovese T, Crisafulli C, Paterniti I, Cuzzocrea E, Bramanti P, Kapoor A, Thiemermann C, Cuzzocrea S: Role of PPAR-delta in the development of zymosan-induced multiple organ failure: an experiment mice study. J Inflamm. 2010 Feb 18;7:12. RESULTS: Treatment with GW0742 caused a significant reduction of the peritoneal exudate formation and of the neutrophil infiltration caused by zymosan resulting in a reduction in myeloperoxidase activity. |
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| 18832772 | Wang XS, Shao B, Oda MN, Heinecke JW, Mahler S, Stocker R: A sensitive and specific ELISA detects methionine sulfoxide-containing apolipoprotein A-I in HDL. J Lipid Res. 2009 Mar;50(3):586-94. Epub 2008 Oct 2. These reactive species include those produced by myeloperoxidase, an enzyme implicated in atherogenesis. |
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| 17676767 | Pattison DI, Hawkins CL, Davies MJ: Hypochlorous acid-mediated protein oxidation: how important are chloramine transfer reactions and protein tertiary structure?. Biochemistry. 2007 Aug 28;46(34):9853-64. Epub 2007 Aug 3. Hypochlorous acid (HOCl) is a powerful oxidant generated from H2O2 and Cl- by the heme enzyme myeloperoxidase, which is released from activated leukocytes. In light of these data, second-order rate constants for reactions of side chain and Gly chloramines with Trp side chains and disulfide bonds have been determined, together with those for further oxidation of Met sulfoxide by HOCl and His side chain chloramines. |
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| 19839600 | Beal JL, Foster SB, Ashby MT: Hypochlorous acid reacts with the N-terminal methionines of proteins to give dehydromethionine, a potential biomarker for neutrophil-induced oxidative stress. Biochemistry. 2009 Nov 24;48(46):11142-8. derivatives of are oxidized to the corresponding sulfoxide derivatives under the same reaction conditions (e.g., Met-3 of anti-inflammatory peptide 1). We suggest that dehydromethionine may be a useful biomarker for the myeloperoxidase-induced oxidative stress associated with many inflammatory diseases. |
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| 18719109 | Shao B, Cavigiolio G, Brot N, Oda MN, Heinecke JW: oxidation impairs reverse transport by apolipoprotein A-I. Proc Natl Acad Sci U S A. 2008 Aug 26;105(34):12224-9. Epub 2008 Aug 21. In humans with established cardiovascular disease, myeloperoxidase (MPO) oxidizes HDL, and oxidation by MPO impairs apoA-I's ability to activate LCAT in vitro. |
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| 19186041 | Domitrovic R, Jakovac H, Milin C, Radosevic-Stasic B: Dose- and time-dependent effects of on carbon tetrachloride-induced hepatotoxicity in mice. Exp Toxicol Pathol. 2009 Nov;61(6):581-9. Epub 2009 Jan 30. The effect of on myeloperoxidase, an indicator of inflammatory cell infiltration, was also investigated. |
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| 18283562 | Yang YL, Huang KL, Liou HL, Chen HI: The involvement of synthase, neutrophil elastase, myeloperoxidase and proinflammatory cytokines in the acute lung injury caused by phorbol J Biomed Sci. 2008 Jul;15(4):499-507. Epub 2008 Feb 19. |
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| 19833874 | Rosen H, Klebanoff SJ, Wang Y, Brot N, Heinecke JW, Fu X: oxidation contributes to bacterial killing by the myeloperoxidase system of neutrophils. Proc Natl Acad Sci U S A. 2009 Nov 3;106(44):18686-91. Epub 2009 Oct 15. |
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| 18086517 | Turan NN, Akar F, Budak B, Seren M, Parlar AI, Surucu S, Ulus AT: How DMSO, a widely used solvent, affects spinal cord injury. Ann Vasc Surg. 2008 Jan;22(1):98-105. Epub 2007 Dec 20. After neurological evaluation at 24 hr of reperfusion, lumbar spinal cords were removed for electron microscopic evaluation and malondialdehyde and myeloperoxidase measurements. |
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| 17511027 | Seo SW, Jung WS, Piao TG, Hong SH, Yun KJ, Park RK, Shin MK, Song HJ, Park SJ: Selective cyclooxygenase-2 inhibitor ameliorates cholecystokinin-octapeptide-induced acute pancreatitis in rats. World J Gastroenterol. 2007 Apr 28;13(16):2298-304. The SC-236 treated group showed minimal histologic evidence of pancreatitis and a significant reduction in myeloperoxidase activity. |
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| 19775156 | Peskin AV, Turner R, Maghzal GJ, Winterbourn CC, Kettle AJ: Oxidation of to dehydromethionine by reactive halogen species generated by neutrophils. Biochemistry. 2009 Oct 27;48(42):10175-82. Purified myeloperoxidase used peroxide and to catalyze the oxidation of N-terminal methionines to dehydromethionine. |
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