Protein Information

Name gelatinases
Synonyms 92 kDa gelatinase; Neutrophil collagenase; 92 kDa type IV collagenase; CLG4B; Collagenase type IV B; Collagenase type V; GEL B; GELB…

Compound Information

Name sulfoxide
CAS 5-[2-(octylsulfinyl)propyl]-1,3-benzodioxole

Reference List

PubMed Abstract RScore(About this table)
20008515 DeNiro M, Al-Halafi A, Al-Mohanna FH, Alsmadi O, Al-Mohanna FA: Pleiotropic effects of YC-1 selectively inhibit pathological retinal neovascularization and promote physiological revascularization in a mouse model of oxygen-induced retinopathy. Mol Pharmacol. 2010 Mar;77(3):348-67. Epub 2009 Dec 14.


Furthermore, YC-1 down-regulated VEGF, erythropoietin, endothelin-1, matrix metalloproteinase-9, and iNOS message and protein levels.
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19436652 Vikman P, Xu CB, Edvinsson L: Lipid-soluble cigarette smoking particles induce expression of inflammatory and extracellular-matrix-related genes in rat cerebral arteries. Vasc Health Risk Manag. 2009;5(1):333-41. Epub 2009 Apr 8.


The expression of matrix metalloproteinase 9 and 13 (MMP9 and MMP13), angiotensin receptor 1 and 2 (AT (1) and AT (2)), interleukin 6 and inducible nitric oxide synthase (iNOS) were investigated at mRNA level by real-time PCR and/or at protein level by immunohistochemistry.
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19909400 Pal S, Chen Z, Xu X, Mikhailova M, Steffensen B: Co-purified gelatinases alter the stability and biological activities of human plasma fibronectin preparations. J Periodontal Res. 2009 Nov 9.

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19006455 Li X, Meng G, Krawetz R, Liu S, Rancourt DE: The ROCK inhibitor Y-27632 enhances the survival rate of human embryonic stem cells following cryopreservation. Stem Cells Dev. 2008 Dec;17(6):1079-85.


The aim of this study was to increase the freeze-thaw survival rate of hES cells by utilizing the ROCK inhibitor Y-27632. hES cell colonies were first treated with Y-27632, followed by collagenase IV and TrypLE Select dissociation whereupon small clumps were slow frozen using 90% Knockout serum replacement and 10% dimethyl sulfoxide.
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17603938 Pradeepkumar Singh L, Kundu P, Ganguly K, Mishra A, Swarnakar S: Novel role of famotidine in downregulation of matrix metalloproteinase-9 during protection of ethanol-induced acute gastric ulcer. Free Radic Biol Med. 2007 Jul 15;43(2):289-99. Epub 2007 Apr 29.

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18183430 Griffith D, Cecco S, Zangrando E, Bergamo A, Sava G, Marmion CJ: Ruthenium (III) dimethyl sulfoxide pyridinehydroxamic acid complexes as potential antimetastatic agents: synthesis, characterisation and in vitro pharmacological evaluation. J Biol Inorg Chem. 2008 May;13(4):511-20.


The solid-state structure of [NBu4][trans-RuCl4 (dmso-S)(4-pyha)] x CH3COCH3 (1) was determined by X-ray crystallography. 2 and 3 were pharmacologically evaluated for their in vitro cytotoxicity, their ability to inhibit cell invasion and their gelatinase activity. 2 and 3 were devoid of cytotoxicity against the cell lines tested. 2 inhibited invasion of the highly invasive MDA-MB-231 cells to a much greater extent than 3.
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19526795 Yang S, Wen H, Zhang G, Zhao S, Luo Y, Lu Q: [Triptolide evaluates DNA methylation level of matrix metalloproteinase 9 gene in human fibrosarcoma HT-1080 cells]. Zhongguo Zhong Yao Za Zhi. 2009 Mar;34(5):611-4.

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