Protein Information

Name caspase (protein family or complex)
Synonyms caspase; caspases

Compound Information

Name sulfoxide
CAS 5-[2-(octylsulfinyl)propyl]-1,3-benzodioxole

Reference List

PubMed Abstract RScore(About this table)
18586875 Sharma A, Neekhra A, Gramajo AL, Patil J, Chwa M, Kuppermann BD, Kenney MC: Effects of Benzo (e) Pyrene, a toxic component of cigarette smoke, on human retinal pigment epithelial cells in vitro. Invest Ophthalmol Vis Sci. 2008 Nov;49(11):5111-7. Epub 2008 Jun 27.


It causes cell death and induces apoptosis by the involvement of multiple caspase pathways.
1(0,0,0,1) Details
17525209 Perche O, Doly M, Ranchon-Cole I: Caspase-dependent apoptosis in light-induced retinal degeneration. . Invest Ophthalmol Vis Sci. 2007 Jun;48(6):2753-9.

3(0,0,0,3) Details
17639882 Iseda K, Ono S, Onoda K, Satoh M, Manabe H, Nishiguchi M, Takahashi K, Tokunaga K, Sugiu K, Date I: Antivasospastic and antiinflammatory effects of caspase inhibitor in experimental subarachnoid hemorrhage. J Neurosurg. 2007 Jul;107(1):128-35.

2(0,0,0,2) Details
18699726 Johnston PA, Soares KM, Shinde SN, Foster CA, Shun TY, Takyi HK, Wipf P, Lazo JS: Development of a 384-well colorimetric assay to quantify hydrogen peroxide generated by the redox cycling of compounds in the presence of reducing agents. Assay Drug Dev Technol. 2008 Aug;6(4):505-18.


Activity was confirmed against a number of targets containing active site cysteines, including protein tyrosine phosphatases, cathepsins, and caspases, as well as a number of cellular cytotoxicity assays.
1(0,0,0,1) Details
19782097 Datta S, Mazumder S, Ghosh D, Dey S, Bhattacharya S: Low concentration of arsenic could induce caspase-3 mediated head kidney macrophage apoptosis with JNK-p38 activation in Clarias batrachus. Toxicol Appl Pharmacol. 2009 Dec 15;241(3):329-38. Epub 2009 Sep 24.


Preincubation with antioxidants N-acetyl-cysteine or dimethyl sulfoxide significantly lowered reactive oxygen species (ROS) levels in arsenic-treated HKM and prevented caspase activation, malondialdehyde formation and HKM apoptosis.
1(0,0,0,1) Details