Protein Information

Name histone deacetylase (protein family or complex)
Synonyms Histone deacetylase; Histone deacetylases

Compound Information

Name sulfoxide
CAS 5-[2-(octylsulfinyl)propyl]-1,3-benzodioxole

Reference List

PubMed Abstract RScore(About this table)
18593248 Kisseberth WC, Murahari S, London CA, Kulp SK, Chen CS: Evaluation of the effects of histone deacetylase inhibitors on cells from canine cancer cell lines. Am J Vet Res. 2008 Jul;69(7):938-45.

2(0,0,0,2) Details
19448855 Gavin DP, Rosen C, Chase K, Grayson DR, Tun N, Sharma RP: Dimethylated lysine 9 of histone 3 is elevated in schizophrenia and exhibits a divergent response to histone deacetylase inhibitors in lymphocyte cultures. J Psychiatry Neurosci. 2009 May;34(3):232-7.

2(0,0,0,2) Details
20118114 Lu Y, Nie J, Liu X, Zheng Y, Guo SW: Trichostatin A, a histone deacetylase inhibitor, reduces lesion growth and hyperalgesia in experimentally induced endometriosis in mice. Hum Reprod. 2010 Apr;25(4):1014-25. Epub 2010 Jan 29.

2(0,0,0,2) Details
19584707 Rahim R, Strobl JS: Hydroxychloroquine, chloroquine, and all-trans retinoic acid regulate growth, survival, and histone acetylation in breast cancer cells. Anticancer Drugs. 2009 Sep;20(8):736-45.


As an earlier study suggested that CQ, HCQ, and ATRA are breast cancer cell differentiation agents, these agents were screened in cell-free histone deacetylase (HDAC) and histone acetyltransferase (HAT) assays.
1(0,0,0,1) Details
19295477 Li Y, Liu B, Zhao H, Sailhamer EA, Fukudome EY, Zhang X, Kheirbek T, Finkelstein RA, Velmahos GC, deMoya M, Hales CA, Alam HB: Protective effect of suberoylanilide hydroxamic acid against LPS-induced septic shock in rodents. Shock. 2009 Nov;32(5):517-23.


We have recently found that suberoylanilide hydroxamic acid (SAHA), a histone deacetylase inhibitor, improves survival in a lethal model of hemorrhagic shock in rats.
1(0,0,0,1) Details