Protein Information

Name extracellular signal regulated kinase 1
Synonyms ERK 1; ERK1; ERT 2; ERT2; Extracellular signal regulated kinase 1; Extracellular signal related kinase 1b; Extracellular signal related kinase 1c; HS44KDAP…

Compound Information

Name sulfoxide
CAS 5-[2-(octylsulfinyl)propyl]-1,3-benzodioxole

Reference List

PubMed Abstract RScore(About this table)
17936423 Craig DH, Zhang J, Basson MD: Cytoskeletal signaling by way of alpha-actinin-1 mediates ERK1/2 activation by repetitive deformation in human Caco2 intestinal epithelial cells. Am J Surg. 2007 Nov;194(5):618-22.

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17459723 Mark JK, Smith S, Hefford MA: Over-expression and refolding of MAP kinase phosphatase 3. Protein Expr Purif. 2007 Aug;54(2):253-60. Epub 2007 Mar 21.


MAP kinase phosphatase 3 (MKP3, also known as DUSP6 and PYST1) is involved in extracellular signal receptor kinase (ERK) regulation and functions as a specific phosphatase to the activated (phosphorylated) forms of ERK1 and ERK2.
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19339661 Fricks IP, Carter RL, Lazarowski ER, Harden TK: Gi-dependent cell signaling responses of the human P2Y14 receptor in model cell systems. J Pharmacol Exp Ther. 2009 Jul;330(1):162-8. Epub 2009 Apr 1.


UDP-Glc promoted concentration-dependent and pertussis toxin-sensitive extracellular signal-regulated kinase (ERK) 1/2 phosphorylation in P2Y (14)-HEK293 cells.
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19047410 Kamda JD, Singer SM: Phosphoinositide 3-kinase-dependent inhibition of dendritic cell interleukin-12 production by Giardia lamblia. Infect Immun. 2009 Feb;77(2):685-93. Epub 2008 Dec 1.


Finally, studies with an extracellular signal-regulated kinase 1/2 pathway inhibitor, a phosphoinositide 3-kinase (PI3K) inhibitor, and anti-IL-10 receptor antibody revealed that the PI3K pathway is the dominant mechanism of inhibition in DCs incubated with both lipopolysaccharide and Giardia.
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20091890 Hui C, Like W, Yan F, Tian X, Qiuyan W, Lifeng H: S-allyl-L-cysteine sulfoxide inhibits tumor necrosis factor-alpha induced monocyte adhesion and intercellular cell adhesion molecule-1 expression in human umbilical vein endothelial cells. Anat Rec. 2010 Mar;293(3):421-30.

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