Protein Information

Name xanthine oxidase
Synonyms XDH; XDHA; XO; XOD; XOR; Xanthene dehydrogenase; Xanthine dehydrogenase; Xanthine dehydrogenase/oxidase…

Compound Information

Name sulfoxide
CAS 5-[2-(octylsulfinyl)propyl]-1,3-benzodioxole

Reference List

PubMed Abstract RScore(About this table)
18670127 Sato E, Mokudai T, Niwano Y, Kamibayashi M, Kohno M: Existence of a new reactive intermediate oxygen species in hypoxanthine and xanthine oxidase reaction. Chem Pharm Bull. 2008 Aug;56(8):1194-7.

2(0,0,0,2) Details
18096847 Andreesen JR, Makdessi K: Tungsten, the surprisingly positively acting heavy metal element for prokaryotes. Ann N Y Acad Sci. 2008 Mar;1125:215-29. Epub 2007 Dec 20.


It starts from an inhibitory element/anion, especially for the iron molybdenum-cofactor (FeMoCo)-containing enzyme nitrogenase involved in dinitrogen fixation, as well as for the many "metal binding pterin" (MPT)-, also known as tricyclic pyranopterin- containing classic molybdoenzymes, such as the sulfite oxidase and the xanthine dehydrogenase family of enzymes.
1(0,0,0,1) Details
17529908 Xing L, Remick DG: Mechanisms of oxidant regulation of monocyte chemotactic protein 1 production in human whole blood and isolated mononuclear cells. Shock. 2007 Aug;28(2):178-85.


Exogenous ROI (either hydrogen peroxide or O2 generated by xanthine/xanthine oxidase) stimulated MCP-1 production, which was also inhibited by DMSO.
1(0,0,0,1) Details
17949278 Xing L, Remick DG: Promoter elements responsible for antioxidant regulation of MCP-1 gene expression. Antioxid Redox Signal. 2007 Nov;9(11):1979-89.


Mutation or deletion of the NF-kappaB binding sites significantly decreased or abolished reporter activity in response to reactive oxygen intermediates (ROI), generated by xanthine plus xanthine oxidase.
1(0,0,0,1) Details
18312271 Kozmin SG, Leroy P, Pavlov YI, Schaaper RM: YcbX and yiiM, two novel determinants for resistance of Escherichia coli to N-hydroxylated base analogues. Mol Microbiol. 2008 Apr;68(1):51-65. Epub 2008 Feb 26.


In the absence of the ycbX- and yiiM-dependent pathways, biotin sulfoxide reductase plays also a role in the detoxification pathway.
0(0,0,0,0) Details