| Name | glutamine transaminase K |
|---|---|
| Synonyms | CCBL 1; CCBL1; CCBL1 protein; Cysteine conjugate beta lyase; Cysteine S conjugate beta lyase; GTK; Glutamine phenylpyruvate aminotransferase; Glutamine transaminase K… |
| Name | sulfoxide |
|---|---|
| CAS | 5-[2-(octylsulfinyl)propyl]-1,3-benzodioxole |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19572755 | Barshteyn N, Elfarra AA: Cysteine conjugate beta-lyase activity of rat erythrocytes and formation of beta-lyase-derived globin monoadducts and cross-links after in vitro exposure of erythrocytes to S-(1,2-dichlorovinyl)- Chem Res Toxicol. 2009 Jul;22(7):1351-8. S-(1,2-Dichlorovinyl)- (DCVC), a mutagenic and nephrotoxic metabolite of trichloroethylene, can be bioactivated to reactive metabolites, S-(1,2-dichlorovinyl)- sulfoxide (DCVCS) or chlorothioketene and/or 2-chlorothionoacetyl by conjugate S-oxidase (S-oxidase) and cysteine conjugate beta-lyase (beta-lyase), respectively. |
82(1,1,1,2) | Details |
| 19694420 | Barshteyn N, Elfarra AA: Globin monoadducts and cross-links provide evidence for the presence of S-(1,2-dichlorovinyl)- sulfoxide, chlorothioketene, and 2-chlorothionoacetyl in the circulation in rats administered S-(1,2-dichlorovinyl)- Chem Res Toxicol. 2009 Sep;22(9):1629-38. S-(1,2-Dichlorovinyl)- (DCVC), a mutagenic and nephrotoxic metabolite of trichloroethylene, is bioactivated to S-(1,2-dichlorovinyl)- sulfoxide (DCVCS) and chlorothioketene and/or 2-chlorothionoacetyl by conjugate S-oxidase (S-oxidase) and cysteine conjugate beta-lyase (beta-lyase), respectively. |
81(1,1,1,1) | Details |
| 18687801 | Dever JT, Elfarra AA: -dl-sulfoxide metabolism and toxicity in freshly isolated mouse hepatocytes: gender differences and inhibition with aminooxyacetic acid. Drug Metab Dispos. 2008 Nov;36(11):2252-60. Epub 2008 Aug 7. Analysis of MetO transamination activity by glutamine transaminase K in mouse liver cytosol revealed similar rates of MetO transamination in cytosol of both genders. |
1(0,0,0,1) | Details |
| 19236888 | Dever JT, Elfarra AA: Gender differences in accumulation and metabolism in freshly isolated mouse hepatocytes: potential roles in toxicity. Toxicol Appl Pharmacol. 2009 May 1;236(3):358-65. Epub 2009 Feb 21. Female hepatocytes also exhibited higher -L-sulfoxide levels relative to control hepatocytes, whereas the increases in -D-sulfoxide (Met-D-O) levels were similar in hepatocytes of both genders. |
0(0,0,0,0) | Details |