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Tshala-Katumbay D, Monterroso V, Kayton R, Lasarev M, Sabri M, Spencer P: Probing mechanisms of axonopathy. Toxicol Sci. 2009 Feb;107(2):482-9. Epub 2008 Nov 25.
Analysis of the lumbosacral proteome by 2-dimensional differential in-gel electrophoresis and matrix-assisted laser desorption ionization time-of-flight/tandem mass spectrometry revealed 34 proteins markedly modified by 2,5-HD of which neurofilament triplet L, gelsolin, protein disulfide isomerase, glutathione S-transferase, nicotinamide adenine dinucleotide (reduced) dehydrogenase 1 alpha, pyruvate kinase, and fatty acid synthase were also modified by 1,2-DAB. |
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