| Name | methionine R sulfoxide reductases |
|---|---|
| Synonyms | HSPC270; MSRB 1; MSRB1; Methionine R sulfoxide reductase; SELR; SELX; SEPX 1; SEPX1… |
| Name | sulfoxide |
|---|---|
| CAS | 5-[2-(octylsulfinyl)propyl]-1,3-benzodioxole |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19923731 | Bong SM, Moon JH, Kim HY, Kim HS, Chi YM, Kim AY: Crystallization and preliminary X-ray crystallographic analysis of free methionine-(R)-sulfoxide reductase from Staphylococcus aureus. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Nov 1;65(Pt 11):1120-2. Epub 2009 Oct 30. Free methionine-(R)-sulfoxide reductase (fRMsr) catalyzes the reduction of the free form of -(R)-sulfoxide back to free |
82(1,1,1,2) | Details |
| 18697736 | Lee BC, Le DT, Gladyshev VN: Mammals reduce -S-sulfoxide with MsrA and are unable to reduce -R-sulfoxide, and this function can be restored with a yeast reductase. J Biol Chem. 2008 Oct 17;283(42):28361-9. Epub 2008 Aug 12. However, SK-Hep1 cells expressing a yeast free methionine-R-sulfoxide reductase proliferated in the presence of either sulfoxide, reduced them, and showed increased resistance to oxidative stress. |
62(0,2,2,2) | Details |
| 18081029 | Kakiuchi C, Ishiwata M, Nanko S, Ozaki N, Iwata N, Umekage T, Tochigi M, Kohda K, Sasaki T, Imamura A, Okazaki Y, Kato T: Up-regulation of ADM and SEPX1 in the lymphoblastoid cells of patients in monozygotic twins discordant for schizophrenia. Am J Med Genet B Neuropsychiatr Genet. 2008 Jul 5;147B(5):557-64. |
4(0,0,0,4) | Details |
| 19457862 | Tarrago L, Laugier E, Zaffagnini M, Marchand C, Le Marechal P, Rouhier N, Lemaire SD, Rey P: Regeneration mechanisms of Arabidopsis thaliana reductases B by glutaredoxins and thioredoxins. J Biol Chem. 2009 Jul 10;284(28):18963-71. Epub 2009 May 20. In the present work we used recombinant plastidial Arabidopsis thaliana MSRB1 and MSRB2 as models for 1-Cys and 2-Cys MSRBs, respectively, to delineate the Trx- and glutaredoxin-dependent reduction mechanisms. |
3(0,0,0,3) | Details |
| 19542914 | Taungjaruwinai WM, Bhawan J, Keady M, Thiele JJ: Differential expression of the antioxidant repair enzyme reductase (MSRA and MSRB) in human skin. Am J Dermatopathol. 2009 Jul;31(5):427-31. Recently, the antioxidant repair enzymes -S-sulfoxide reductase A (MSRA) and methionine-R-sulfoxide reductase B (MSRB) were described in human epidermal keratinocytes and melanocytes. We sought to examine the expression and distribution of this enzyme family (MSRA, MSRB1, MSRB2, and MSRB3) within the various compartments of healthy and diseased human skin. |
2(0,0,0,2) | Details |
| 17761174 | Vieira Dos Santos C, Laugier E, Tarrago L, Massot V, Issakidis-Bourguet E, Rouhier N, Rey P: Specificity of thioredoxins and glutaredoxins as electron donors to two distinct classes of Arabidopsis plastidial reductases B. FEBS Lett. 2007 Sep 18;581(23):4371-6. Epub 2007 Aug 14. Using recombinant proteins, we show that Arabidopsis plastidial MSRB1 and MSRB2, which differ regarding the number of presumed redox-active cysteines, possess specific reductants. |
2(0,0,0,2) | Details |
| 20236937 | Tarrago L, Laugier E, Zaffagnini M, Marchand CH, Le Marechal P, Lemaire SD, Rey P: The plant thioredoxin CDSP32 regenerates 1-CYS methionine sulfoxide reductase B activity through the direct reduction of sulfenic acid. J Biol Chem. 2010 Mar 17. Protein electrophoresis analyses coupled to mass spectrometry revealed that CDSP32 forms a heterodimeric complex with MSRB1 via reduction of the sulfenic acid formed on MSRB1 catalytic Cys after MetSO reduction. |
2(0,0,0,2) | Details |
| 19874542 | Laugier E, Tarrago L, Dos Santos CV, Eymery F, Havaux M, Rey P: Arabidopsis thaliana plastidial reductases B, MSRBs, account for most leaf peptide MSR activity and are essential for growth under environmental constraints through a role in the preservation of photosystem antennae. Plant J. 2010 Jan;61(2):271-82. Epub 2009 Oct 26. Two MSRB isoforms, MSRB1 and MSRB2, are present in chloroplasts of Arabidopsis thaliana. |
2(0,0,0,2) | Details |
| 19788859 | Kwak GH, Choi SH, Kim JR, Kim HY: Inhibition of reduction by . BMB Rep. 2009 Sep 30;42(9):580-5. Previous reports described DMSO as being reduced by -S-sulfoxide reductase (MsrA). However, little is known about the DMSO reduction capability of methionine-R-sulfoxide reductase (MsrB) or its effect on the catalysis of reduction. |
1(0,0,0,1) | Details |
| 19049972 | Le DT, Lee BC, Marino SM, Zhang Y, Fomenko DE, Kaya A, Hacioglu E, Kwak GH, Koc A, Kim HY, Gladyshev VN: Functional analysis of free methionine-R-sulfoxide reductase from Saccharomyces cerevisiae. J Biol Chem. 2009 Feb 13;284(7):4354-64. Epub 2008 Dec 2. MsrA and MsrB are the best known Msrs that repair -S-sulfoxide (Met-S-SO) and -R-sulfoxide (Met-R-SO) residues in proteins, respectively. |
1(0,0,0,1) | Details |
| 18990697 | Fomenko DE, Novoselov SV, Natarajan SK, Lee BC, Koc A, Carlson BA, Lee TH, Kim HY, Hatfield DL, Gladyshev VN: MsrB1 (methionine-R-sulfoxide reductase 1) knock-out mice: roles of MsrB1 in redox regulation and identification of a novel selenoprotein form. J Biol Chem. 2009 Feb 27;284(9):5986-93. Epub 2008 Nov 6. residues are particularly susceptible to oxidation, but the resulting mixture of R-sulfoxide (Met-RO) and S-sulfoxide (Met-SO) can be repaired by thioredoxin-dependent enzymes MsrB and MsrA, respectively. |
1(0,0,0,1) | Details |
| 17943184 | Schallreuter KU, Rubsam K, Gibbons NC, Maitland DJ, Chavan B, Zothner C, Rokos H, Wood JM: reductases A and B are deactivated by peroxide (H2O2) in the epidermis of patients with vitiligo. J Invest Dermatol. 2008 Apr;128(4):808-15. Epub 2007 Oct 18. Such high concentrations of H (2) O (2) oxidize residues in proteins and peptides to (R and sulfoxide diasteriomers. Also, we used recombinant human MSRA and MSRB1 to show that both enzymes are deactivated by 10 (-3) M H (2) O (2) by 85 and 40%, respectively. |
1(0,0,0,1) | Details |
| 19636847 | Sal LS, Aachmann FL, Kim HY, Gladyshev VN, Dikiy A: NMR assignments of 1H, 13C and 15N spectra of reductase B1 from Mus musculus. Biomol NMR Assign. 2007 Jul;1(1):131-3. Epub 2007 Jul 31. Isotopically labeled, 15N and 15N/13C forms of recombinant methionine-r-sulfoxide reductase 1 (MsrB1, SelR) from Mus musculus were produced, in which catalytic was replaced with |
1(0,0,0,1) | Details |
| 17535911 | Lin Z, Johnson LC, Weissbach H, Brot N, Lively MO, Lowther WT: Free methionine-(R)-sulfoxide reductase from Escherichia coli reveals a new GAF domain function. Proc Natl Acad Sci U S A. 2007 Jun 5;104(23):9597-602. Epub 2007 May 29. |
1(0,0,0,1) | Details |
| 19636904 | Breivik AS, Aachmann FL, Sal LS, Kim HY, Del Conte R, Gladyshev VN, Dikiy A: 1H, 15N and 13C NMR assignments of mouse methionine sulfoxide reductase B2. Biomol NMR Assign. 2008 Dec;2(2):199-201. Epub 2008 Oct 4. A recombinant mouse methionine-r-sulfoxide reductase 2 (MsrB2 Delta S) isotopically labeled with (15) N and (15) N/(13) C was generated. |
1(0,0,0,1) | Details |
| 19409408 | Shchedrina VA, Vorbruggen G, Lee BC, Kim HY, Kabil H, Harshman LG, Gladyshev VN: Overexpression of methionine-R-sulfoxide reductases has no influence on fruit fly aging. Mech Ageing Dev. 2009 Jul;130(7):429-43. Epub 2009 May 3. There are two known Msr types in animals: MsrA specific for the reduction of -S-sulfoxide, and MsrB that catalyzes the reduction of -R-sulfoxide. |
0(0,0,0,0) | Details |