Protein Information

Name lymphokine
Synonyms 519; lymphokine; D2S69E; GNLY; Granulysin; Granulysin precursor; LAG 2; LAG2…

Compound Information

Name dichlorvos
CAS 2,2-dichloroethenyl dimethyl phosphate

Reference List

PubMed Abstract RScore(About this table)
18063463 Li Q, Kobayashi M, Kawada T: DDVP markedly decreases the expression of granzyme B and granzyme 3/K in human NK cells. Toxicology. 2008 Jan 20;243(3):294-302. Epub 2007 Oct 26.

We have found previously that dimethyl 2,2-dichlorovinyl phosphate (DDVP, dichlorvos), an organophosphorus pesticide, significantly decreased the expression of perforin, granzyme A (GrA), and granulysin and inhibited NK, LAK, and CTL activities.
32(0,1,1,2) Details
16002202 Li Q, Nakadai A, Ishizaki M, Morimoto K, Ueda A, Krensky AM, Kawada T: Dimethyl 2,2-dichlorovinyl phosphate (DDVP) markedly decreases the expression of perforin, granzyme A and granulysin in human NK-92CI cell line. Toxicology. 2005 Sep 15;213(1-2):107-16.

7(0,0,0,7) Details
15369847 Li Q, Nakadai A, Takeda K, Kawada T: Dimethyl 2,2-dichlorovinyl phosphate (DDVP) markedly inhibits activities of natural killer cells, cytotoxic T lymphocytes and lymphokine-activated killer cells via the Fas-ligand/Fas pathway in perforin-knockout (PKO) mice. Toxicology. 2004 Nov 1;204(1):41-50.

2(0,0,0,2) Details
11893417 Li Q, Nagahara N, Takahashi H, Takeda K, Okumura K, Minami M: Organophosphorus pesticides markedly inhibit the activities of natural killer, cytotoxic T lymphocyte and lymphokine-activated killer: a proposed inhibiting mechanism via granzyme inhibition. Toxicology. 2002 Apr 2;172(3):181-90.

2(0,0,0,2) Details