| 2140075 |
Yoshida M, Shimokura M, Fujiwara Y, Fujisaki T, Akaji K, Kiso Y: Solution-phase synthesis of alpha-human atrial natriuretic peptide (alpha-hANP). Chem Pharm Bull. 1990 Feb;38(2):382-8.
Alpha-human atrial natriuretic peptide (alpha-hANP) was synthesized by assembling six peptide fragments in solution followed by deprotection with HF and subsequent air-oxidation. The trimethylbenzyl group was employed as an S-protecting group of cysteine. The HF-dimethylselenide-m-cresol system was employed as a final deprotecting reagent and, at the same time, as a reducing reagent of Met (O). Synthetic alpha-hANP elicited potent diuretic and natriuretic activity in rats. |
2(0,0,0,2) |