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Abiko T, Sekino H: Synthesis of [Phe (4F) 3] thymopoietin II and examination of its immunological effect on the impaired blastogenic response of T-lymphocytes of uremic patients. Bioorg Med Chem. 1995 Oct;3(10):1369-75.
[Phe (4F) 3] thymopoietin II was synthesized using a conventional solution method. The deprotection of the protected [Phe (4F) 3] thymopoetin II was achieved by treatment with 1 M trifluoromethanesulfonic acid:thioanisole (molar ratio 1:1) in trifluoroacetic acid in the presence of dimethylselenide and m-cresol. The synthetic f1p4 (4F) 3] thymopoietin II and thymopoietin II were tested for effect on impaired T-lymphocyte transformation by phytohemagglutinin in uremic patients suffering from recurrent infectious diseases. The restoring activity on the impaired phytohemagglutinin stimulation of T-lymphocytes was obtained after incubation of peripheral lymphocytes isolated from uremic patients with the synthetic [Phe (4F) 3] thymopoietin II. This peptide exhibited far stronger restoring effect than that of our synthetic thymopoietin II. |
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