| 1356410 |
Tamaki K, Saitoh A, Yasaka N: Differential effect of griseofulvin on interferon-gamma-induced HLA-DR and intercellular adhesion molecule-1 expression of human keratinocytes. Br J Dermatol. 1992 Sep;127(3):258-61.
Interferon-gamma (IFN-gamma) induces major histocompatibility complex (MHC) class II antigen and intercellular adhesion molecule-1 (ICAM-1) expression on human epidermal keratinocytes. Griseofulvin, an extensively used antifungal agent, has been used effectively in the treatment of lichen planus, in which keratinocytes express both HLA-DR and ICAM-1 antigens. In this study, we investigated the effect of griseofulvin on IFN-gamma-induced MHC class II antigen and ICAM-1 expression of keratinocytes, and demonstrated that griseofulvin decreased IFN-gamma-induced HLA-DR but not ICAM-1 expression. |
13(0,0,2,3) |