| 17617553 |
Nogrady N, Toth A, Kostyak A, Paszti J, Nagy B: Emergence of multidrug-resistant clones of Salmonella Infantis in broiler chickens and humans in Hungary. J Antimicrob Chemother. 2007 Sep;60(3):645-8. Epub 2007 Jul 6.
OBJECTIVES: The characterization of a Salmonella Infantis strain collection that was set up from isolates of animal and human origin obtained in Hungary in recent years. METHODS: All isolates were phage typed. Antimicrobial resistance was tested by the disc diffusion method, while the presence of the antimicrobial resistance genes and class 1 integrons was investigated by PCR. Genetic relatedness of the isolates was tested by PFGE and plasmid profiling. RESULTS: The majority of the isolates representing different parts of Hungary are characterized by phage types 213 and 217 and the nalidixic acid-streptomycin-sulphonamide-tetracycline resistance type. They harbour a class 1 integron with an aadA1 gene in the 855 bp variable region, a tet (A) gene, a > 168 kb plasmid and 66% of them represent one genetic clone as determined by XbaI PFGE fingerprinting. CONCLUSIONS: It seems that broiler chickens constitute a reservoir for one large and a few smaller multidrug-resistant Salmonella Infantis clones in Hungary, which might have spread to humans through chicken meat. |
2(0,0,0,2) |