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Filipova M, Bujdakova H, Drahovska H, Liskova A, Hanzen J: Occurrence of aminoglycoside-modifying-enzyme genes aac (6')-aph (2"), aph (3'), ant (4') and ant (6) in clinical isolates of Enterococcus faecalis resistant to high-level of gentamicin and amikacin. Folia Microbiol. 2006;51(1):57-61.
The genes coding for 4 aminoglycoside-modifying enzymes AAC (6')-APH (2"), APH (3'), ANT (4') and ANT (6) were determined in 44 Slovak clinical isolates of Enterococcus faecalis with high-level resistance to gentamicin (HLGR, collection 1) and 48 E. faecalis isolates with resistance to amikacin (AR, collection 2). The occurrence of spotted genes was (collection 1 vs. collection 2): aac (6)-aph (2") 81.8 vs. 8.3 %, ant (4') 52.3 vs. 81.3 %, aph (3') 50 vs. 56.3 % and ant (6) 6.8 vs. 4.2 %, the most frequent combinations of genes in the HLGR collection were aac (6')-aph (2") + ant (4') and aac (6')-aph (2") + aph (3). In contrast, the aph (3') + ant (4') gene profile was predominant in AR isolates. None of the isolates contained all four AGME genes simultaneously. |
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