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Brown HR, Sharma RP: Synaptosomal adenosine triphosphatase (ATPase) inhibition by organophosphates. Experientia. 1976 Dec 15;32(12):1540-2.
Chicken spinal cord adenosine triphosphatases (both Na+, K+ stimulated and ouabain insensitive) were inhibited by tri-o-tolyl phosphate (TOTP, a neurotoxic organophosphate which is not a cholinesterase inhibitor) and mevinphos (a non-neurotoxic compound but inhibitor of cholinesterases). The inhibition was concentration and time dependent, with an initial rapid drop in activity followed by a gradual exponential decline. |
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