| 12508136 |
Ramalingam V, Vimaladevi V: Effect of mercuric chloride on membrane-bound enzymes in rat testis. . Asian J Androl. 2002 Dec;4(4):309-11.
AIM: To study the effect of mercuric chloride on the membrane-bound enzymes. METHODS: The effect of mercuric chloride at two different doses, 1 mg/kg (low dose) and 2 mg/kg (high dose), orally for 30 days, was observed on the membrane-bound enzymes in the testis of adult albino rats. RESULTS: Mercuric chloride significantly decreased the body weight and testis weight in the high dose group (P < 0.05), but not in the low dose group. The activities of 5'nucleotidase and adenosine triphosphatases were markedly decreased (P < 0.01) in the testis of both groups. Alkaline phosphatase and ggr-glutamyl transferase activities were significantly increased (P < 0.01) in both groups. However, the effect was more pronounced in the high than in the low dose groups. CONCLUSION: The dose dependent effect of mercuric chloride on these enzymes may affect the membrane characteristics and thereby the fertility of the animal. |
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