| 10379950 |
Okada H, Miyake Y, Ohtsuka H, Kiku Y, Fukuda S, Watanabe A, Yokomizo Y, Rosol TJ, Yoshino T: Effects of isoprothiolane on cell growth of cultured bovine mammary epithelial cells. J Vet Med Sci. 1999 May;61(5):553-6.
This study was performed to investigate the effects of isoprothiolane on cell growth and the production of interleukin (IL)-1 and IL-6 by bovine mammary epithelial cells in vitro. Isoprothiolane increased proliferation of mammary epithelial cells in a dose-dependent manner at the concentration of 0.05 to 5 microM when cultured either with or without serum-supplemented medium. In contrast, isoprothiolane (0.0005-5 microM) significantly inhibited the production of IL-1 and IL-6 by mammary epithelial cells. Moreover, the cytokines, IL-1alpha, IL-1beta, IL-6, and tumor necrosis factor (TNF)-alpha tended to inhibit the proliferation of mammary epithelial cells in a dose-dependent manner. These results indicated that isoprothiolane regulated mammary epithelial cell growth in vitro possibly by modulating the production of cytokines. |
163(2,2,2,3) |