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Bellocco E, Barreca D, Lagana G, Leuzzi U, Tellone E, Ficarra S, Kotyk A, Galtieri A: Influence of L-rhamnosyl-D-glucosyl derivatives on properties and biological interaction of flavonoids. Mol Cell Biochem. 2009 Jan;321(1-2):165-71. Epub 2008 Nov 6.
The anti-proliferative activity of hesperetin, hesperidin, neohesperidin and rutin was evaluated on human hepatoma cell lines (Hep G2) and correlated to their antioxidant activity. The results obtained showed strong anti-proliferative effects of hesperidin and neohesperidin, considerably higher than the other two additives. Hesperetin induced caspase-3 activation, release of LDH and endogenous accumulation of putrescine. Cell cycle distribution seems to indicate that the inhibitory effects of polyphenols on cell growth could be due to G0/G1 block, and activation of apoptotic pathway in the presence of hesperetin. Our results underline also that the glycone forms show reduced scavenging activity against DPPH, but present a remarkable inhibition of cell proliferation and low cytotoxicity. |
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