| 19902964 |
Williams AB, Weiser PT, Hanson RN, Gunther JR, Katzenellenbogen JA: Synthesis of biphenyl proteomimetics as estrogen receptor-alpha coactivator binding inhibitors. Org Lett. 2009 Dec 3;11(23):5370-3.
A novel series of biphenyl proteomimetic compounds were designed as estrogen receptor-alpha (ER (alpha)) coactivator binding inhibitors. Synthesis was accomplished through a convergent approach, employing Suzuki coupling chemistry to ligate the individual modular units. Initial biological results support the ability of these compounds to compete for the ER (alpha) coactivator binding groove. |
63(0,2,2,3) |