| 17986791 |
Morimura K, Yamazaki C, Hattori Y, Makabe H, Kamo T, Hirota M: A tyrosinase inhibitor, Daedalin A, from mycelial culture of Daedalea dickinsii. Biosci Biotechnol Biochem. 2007 Nov;71(11):2837-40. Epub 2007 Nov 7.
A chromene-type compound, daedalin A (1), was isolated from mycelial culture broth of Daedalea dickinsii. Based on spectroscopic data, the structure of 1 was found to be (2R)-6-hydroxy-2-hydroxymethyl-2-methyl-2H-chromene. Daedalin A (1) strongly inhibited the activity of tyrosinase (IC (50): 194 muM). In addition, 1 also showed 1,1-diphenyl-2-picrylhydrazyl scavenging activity (IC (50): 16.9 microM) and superoxide anion scavenging activity (IC (50): 28.5 microM). |
2(0,0,0,2) |