| 19103483 |
Derbre S, Lecat-Guillet N, Pillon F, Ambroise Y: Synthesis and evaluation of photoreactive probes to elucidate iodide efflux in thyrocytes. Bioorg Med Chem Lett. 2009 Feb 1;19(3):825-7. Epub 2008 Dec 7.
Four photoreactive analogues of 3-biphenyl-4'-yl-5,6-dihydroimidazo [2,1-b] thiazole were prepared and evaluated as iodide sequestering agents in sodium iodide symporter-expressing cells. One of these new photoactivatable compounds retained biological activity and was further radiolabeled with tritium. This compound may provide a useful tool for labeling, purification, and identification of target protein responsible for iodide efflux in thyrocytes. |
6(0,0,1,1) |