| 19137910 |
Cirauqui N, Ceras J, Galiano S, Perez-Silanes S, Juanenea L, Rivera G, Aldana I, Monge A: New amide derivatives as melanin-concentrating hormone receptor 1 antagonists for the treatment of obesity. Arzneimittelforschung. 2008;58(11):585-91.
Melanin-concentrating hormone (MCH) is a recently discovered central nervous system (CNS) target for treating obesity. Two novel series of amide derivatives were synthesized and evaluated biologically as MCH-R1 (melanin-concentrating hormone receptor 1) antagonists. The results showed that diphenyl substituents on the amide lead to better activity than biphenyl substituents. |
2(0,0,0,2) |