| 19804972 |
Shi S, Zhu S, Gerritz SW, Rachwal B, Ruan Z, Hutchins R, Kakarla R, Sofia MJ, Sutton J, Cheney D: Solid-phase synthesis of a library based on biphenyl-containing trypsin-like serine protease inhibitors. Bioorg Med Chem Lett. 2009 Nov 15;19(22):6477-80. Epub 2009 Sep 17.
The solid-phase synthesis of a library based on an unusual biphenyl-containing trypsin-like serine protease inhibitor is described. Key to this effort was the synthesis of a highly functionalized aryl boronic acid reagent which required the development of a novel and efficient method to convert a triflate to a pinacolboronate in large scale. |
62(0,2,2,2) |