| 10739033 |
Wittsiepe J, Kullmann Y, Schrey P, Selenka F, Wilhelm M: Myeloperoxidase-catalyzed formation of PCDD/F from chlorophenols. Chemosphere. 2000 May-Jun;40(9-11):963-8.
Chlorophenols (CP) are transformed in vitro to polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/F) by a biochemical-catalyzed oxidation. This is shown for 2,4,5-tri-, 2,3,4,6-tetra-and pentachlorophenol with myeloperoxidase recovered from human leucocytes in the presence of hydrogen peroxide. The yield, the reaction, and the PCDD/F-pattern found depend on the CP. The formation rates are in the micromol-per-mol range for all substrates. The experiments confirm the suspicion that a biochemical formation of PCDD/F from precursors such as CPs can take place in the human body and that this metabolic pathway may lead to a higher inner exposure with PCDD/F than is now assumed. |
7(0,0,1,2) |