| 17658843 |
Bogar K, Vidal PH, Leon AR, Backvall JE: Chemoenzymatic dynamic kinetic resolution of allylic alcohols: a highly enantioselective route to acyloin acetates. Org Lett. 2007 Aug 16;9(17):3401-4. Epub 2007 Jul 21.
Dynamic kinetic resolution (DKR) of a series of sterically hindered allylic alcohols has been conducted with Candida antarctica lipase B (CALB) and ruthenium catalyst 1. The optically pure allylic acetates obtained were subjected to oxidative cleavage to give the corresponding acylated acyloins in high yields without loss of chiral information. |
1(0,0,0,1) |