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Varela A, Montero CG, Cordoba M, Antequera A, Perez M, Tabuenca MJ, Ortiz Berrocal J, Tendillo FJ, Mascias A, Santos M, Castillo Olivares JL: Improved distribution of pulmonary flush solution to the tracheobronchial wall in pulmonary transplantation. Eur Surg Res. 1997;29(1):1-4.
This report describes the experimental results obtained with conventional (pulmonary artery, PA) flushing versus retrograde perfusion (via left atrium, LA) using 99mTc-labeled macroaggregated albumin (MAA-99mTc) to ascertain the distribution throughout the tracheobronchial (TB) tree in 10 Large-White pigs. Lung preservation was achieved with 4 degrees C Euro-Collins solution (60 ml/kg) instilled via PA (n = 5) or LA (n = 5). Simultaneously, MAA-99mTc was given using the same respective route and the isotope uptake quantified at different TB levels after heart-lung block harvest and dissection of all tissue adjacent to TB: proximal and distal trachea and right and left main bronchi. Retrograde distribution resulted in a significantly higher 99mTc count compared to the PA route (p < 0.01). |
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