| 11829942 |
Liang L, Huang J, Yin X, Lu M, Rao G, Ren Z, Li D, Kuang M: [Hepatic arterial infusion of 32P-radionuclide microspheres for radiation therapy of hepatocellular carcinoma]. Zhonghua Wai Ke Za Zhi. 1999 Dec;37(12):743-6.
OBJECTIVE: To investigate the efficacy of internal radiation of (32) P-glass microspheres ((32) P-GMS) in unresected hepatocellular carcinoma (HCC) via subcutaneous arterial port. METHODS: Hepatic arterial (99) technetium-macroaggregate albumin ((99) Tc-MAA) scanning via subcutaneous arterial port was undertaken to measure lung/liver shunting ratio and tumor/liver ratio. Hepatic arterial infusion of (32) P-GMS was performed in 17 cases of HCC with a dose from 1.11 to 1.30 GBq. Twenty cases of HCC undergoing hepatic arterial chemoembolization (HACE) in the same period served as controls group. RESULTS: There was no treatment-related death in the 17 cases. In 7 of the 17 cases, AFP level and/or tumor size decreased by 50% after treatment, with a response rate of 64.7%. The median survival time was 5.5 months, and the 3-, 6-, 9-, 12-month survival rates were 94.1%, 44.1%, 31.0%, 24.4%, respectively. The therapeutic efficacy was better than that of HACE. The survival time was significantly longer in patients with T/N ratio > or= 2 than in those with T/N < 2 (P < 0.05). CONCLUSIONS: Hepatic arterial infusion of (32) P-GMS is an alternative treatment for unresected HCC. |
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