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Yariv J, Kalb AJ, Helliwell JR, Papiz MZ, Bauminger ER, Nowik I: Chemical and Mossbauer spectroscopic evidence that iron-containing concanavalin A is a ferritin. J Biol Chem. 1988 Sep 25;263(27):13508-10.
We report here the preparation of iron-containing concanavalin A. It has a protein-to-iron ratio of 2.0, and the iron compound it contains is particulate with an average diameter of 85 A. Iron-containing concanavalin A interacts reversibly with dextran and with methyl alpha-D-glucoside. The molecular basis of these findings is discussed and a possible mechanism suggested where one of the molecular forms of concanavalin A has the structure of an apoferritin into which iron is deposited in the form of ferrihydrite. |
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