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Page EA, Harrison JF, Jaldow EJ, Kopelman M: Impairment of short-term memory associated with low iron stores in a volunteer multidose plateletpheresis donor. Transfus Med. 2008 Oct;18(5):312-4.
A platelet donor may lose 80-100 mL of blood both in the harness and by blood sampling at each donation, the equivalent of four to five whole blood donations per annum for a donor attending at 2-weekly intervals. A 54-year-old male multidose platelet donor had donated platelets at regular 2-weekly intervals for 6 years. He developed an impairment of anterograde memory (new learning). A self-rating scale revealed a moderate degree of depression [Beck Depression Inventory (BDI) score 22]. Memory testing (Doors and People Memory Battery) showed low scores, particularly for verbal recall and verbal recognition memory. He was found to have a normal haemoglobin of 157 g L (-1) with normal red blood cell indices, but a low serum ferritin (15 ng mL (-1)) and a low serum iron (8.1 mmol L (-1)). Following iron therapy and a return of his iron stores to normal levels, there was an improved BDI score of 13 (minimal level of depression) and a marked improvement in memory test scores. This has been maintained even though he has resumed platelet donation but at reduced intervals. |
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