| 10983974 |
Popperl H, Rikhof H, Chang H, Haffter P, Kimmel CB, Moens CB: lazarus is a novel pbx gene that globally mediates hox gene function in zebrafish. Mol Cell. 2000 Aug;6(2):255-67.
Individual vertebrate Hox genes specify aspects of segment identity along the anterior-posterior axis. The exquisite in vivo specificity of Hox proteins is thought to result from their interactions with members of the Pbx/Exd family of homeodomain proteins. Here, we report the identification and cloning of a zebrafish gene, lazarus, which is required globally for segmental patterning in the hindbrain and anterior trunk. We show that lazarus is a novel pbx gene and provide evidence that it is the primary pbx gene required for the functions of multiple hox genes during zebrafish development. lazarus plays a critical role in orchestrating the corresponding segmentation of the hindbrain and the pharyngeal arches, a key step in the development of the vertebrate body plan. |
81(1,1,1,1) |