Protein Information

ID 2230
Name homeodomain protein
Synonyms Homeobox protein Meis3; Homeobox protein Meis3 variant; Homeodomain protein; MEIS 3; MEIS3; MRG2; Meis1 myeloid ecotropic viral integration site 1 homolog 3; Meis1 related protein 2…

Compound Information

ID 1104
Name EXD
CAS

Reference

PubMed Abstract RScore(About this table)
9346235 Rieckhof GE, Casares F, Ryoo HD, Abu-Shaar M, Mann RS: Nuclear translocation of extradenticle requires homothorax, which encodes an extradenticle-related homeodomain protein. Cell. 1997 Oct 17;91(2):171-83.
We show that homothorax (hth) is required for the Hox genes to pattern the body of the fruit fly, Drosophila melanogaster. hth is necessary for the nuclear localization of an essential HOX cofactor, Extradenticle (EXD), and encodes a homeodomain protein that shares extensive identity with the product of Meis1, a murine proto-oncogene. MEIS1 is able to rescue hth mutant phenotypes and can induce the cytoplasmic-to-nuclear translocation of EXD in cell culture and Drosophila embryos. Thus, Meis1 is a murine homolog of hth. MEIS1/HTH also specifically binds to EXD with high affinity in vitro. These data suggest a novel and evolutionarily conserved mechanism for regulating HOX activity in which a direct protein-protein interaction between EXD and HTH results in EXD's nuclear translocation.
2(0,0,0,2)