| 3567333 |
Panchenko LF, Pirozhkov SV, Popova SV, Antonenkov VD: [Effect of ethanol and the catalase inhibitor aminotriazole on lipid peroxidation in the rat myocardium]. Biull Eksp Biol Med. 1987 Apr;103(4):407-10.
The influence of chronic alcohol consumption and catalase inhibitor aminotriazole administration on the level of nonenzymatic lipid peroxidation has been studied in the rat myocardium. It was demonstrated that combined as well as separate treatment with ethanol or aminotriazole elevated the levels of chemiluminescence and enhanced the rate of accumulation of thiobarbituric acid-reactive products in the nuclei-free and total particulate fraction of the rat heart homogenate. The most pronounced effect was noted during combined application of ethanol and aminotriazole. The induction of chemiluminescence by ethanol was prevented by addition of natural (vitamin E, reduced glutathione) or artificial (dibunol) antioxidants into the incubation media. A putative role of the myocardial catalase-containing micro-peroxisomes in stimulation of the intracellular lipid peroxidation is discussed. |
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