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Metodiewa D, Dunford HB: 3-Aminotriazole is a substrate for lactoperoxidase but not for catalase. . Biochem Biophys Res Commun. 1991 Oct 31;180(2):585-90. Rapid scan spectrophotometry has been applied to investigate the reaction of 3-aminotriazole with mammalian heme enzymes, represented by lactoperoxidase and bovine liver catalase. The results clearly indicate that 3-aminotriazole is a substrate for lactoperoxidase compounds I, II and III, but it does not convert catalase compound I to II under conditions favoring peroxidatic activity of the enzyme. The possible physiological significance of these findings is discussed. |
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