Protein Information

ID 1729
Name acetolactate synthase
Synonyms Acetolactate synthase; OR10B1P

Compound Information

ID 1218
Name tribenuron
CAS 2-[[[[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)methylamino]carbonyl]amino]sulfonyl]benzoic acid

Reference

PubMed Abstract RScore(About this table)
16083111 Fan ZJ, Ai YW, Qian CF, Li ZM: Herbicide activity of monosulfuron and its mode of action. J Environ Sci. 2005;17(3):399-403.
Monosulfuron was developed for weed control in the field of wheat (Triticum, aestivum L.) and millet (Panicum miliaceum L.) with the application rate ranging from 15 to 60 g ai/hm2. Herbicidal activity of monosulfuron was evaluated systematically by bioassay using maize (Zea mays L.) taproot as indicator and weed fresh weight of Acalypha australis L. and Echinochloa phyllopogon. Maize CAU 3138 was the most tolerant cultivars to monosulfuron with IC50 (concentration of 50% inhibition) of 85 microg/kg, Yedan 13 was one of the most sensitive cultivars to monosulfuron with IC50 of 6.4 microg/kg. Monosulfuron inhibited the growth of Acalypha australis L. strongly comparing with that of Echinochloa phyllopogon. Monosulfuron was a good acetolactate synthase (ALS) inhibitor in vitro, the I50 (50% of inhibition) of monosulfuron, chlorsulfuron, tribenuron-methyl and nicosulfuron for CAU 3138 were 32, 2, 19 and 26 nmol/L respectively, for Yedan 13 the I50 were 15, 3, 17 and 65 nmol/L respectively. In vivo ALS inhibition occurred only in higher concentration of 4 sulfonylurea herbicide tested. Comparison study of this test indicated that the mode of action of monosulfuron was the same as that of other sulfonylurea herbicides such as chlorsulfuron, tribenuron-methyl and nicosulfuron, they were all inhibitors targeted at the ALS.
31(0,1,1,1)