| 3382415 |
Scott TR, Kirsch RE: Inhibition of rat liver glutathione S-transferase isoenzymes by acrolein. . Biochem Int. 1988 Mar;16(3):439-42.
The in vitro effect of the toxin and teratogen, acrolein, on the fetal rat liver glutathione S-transferase isoenzyme, YcYfetus, was investigated and compared with acrolein's effect on some of the adult rat liver glutathione S-transferase isoenzymes. Acrolein was found to inhibit all the isoenzymes investigated and double-reciprocal plots suggest that inhibition is either noncompetitive or mixed-type noncompetitive. It is therefore attractive to suggest that should a similar situation arise in vivo, it may provide one mechanism for the teratogenicity of acrolein. |
87(1,1,2,2) |