Protein Information

ID 103
Name adenylyl cyclase
Synonyms ADCY 7; ATP pyrophosphate lyase; Adenylyl cyclase; ADCY7; ADCY7 protein; ATP pyrophosphate lyase 7; Adenylate cyclase 7; Adenylate cyclase type 7…

Compound Information

ID 1388
Name sodium fluoride
CAS sodium fluoride (NaF)

Reference

PubMed Abstract RScore(About this table)
11029293 Pei JM, Yu XC, Fung ML, Zhou JJ, Cheung CS, Wong NS, Leung MP, Wong TM: Impaired G (s) alpha and adenylyl cyclase cause beta-adrenoceptor desensitization in chronically hypoxic rat hearts. Am J Physiol Cell Physiol. 2000 Nov;279(5):C1455-63.
The effects of beta-adrenoceptor stimulation with isoproterenol on electrically induced contraction and intracellular calcium ([Ca (2+)](i)) transient, and cAMP in myocytes from both hypertrophied right and nonhypertrophied left ventricles of rats exposed to 10% oxygen for 4 wk, were significantly attenuated. The increased [Ca (2+)](i) transient in response to cholera toxin was abolished, whereas increased cAMP after NaF significantly attenuated. The biologically active isoform, G (s) alpha-small (45 kDa), was reduced while the biologically inactive isoform, G (s) alpha-large (52 kDa), increased. The increased electrically induced [Ca (2+)](i) transient and cAMP with 10-100 microM forskolin were significantly attenuated in chronically hypoxic rats. The content of G (i) alpha (2), the predominant isoform of G (i) protein in the heart, was unchanged. Results indicate that impaired functions of G (s) protein and adenylyl cyclase cause beta-adrenoceptor desensitization. The impaired function of the G (s) protein may be due to reduced G (s) alpha-small and/or increased G (s) alpha-large, which does not result from changes in G (i) protein. Responses to all treatments were the same for right and left ventricles, indicating that the impaired cardiac functions are not secondary to cardiac hypertrophy.
2(0,0,0,2)