| 14584934 |
Wu YJ, He H, Hu S, Huang Y, Scola PM, Grant-Young K, Bertekap RL, Wu D, Gao Q, Li Y, Klakouski C, Westphal RS: Identification of a potent and selective 5-HT (6) antagonist: one-step synthesis of (E)-3-(benzenesulfonyl)-2- (methylsulfanyl) pyrido [1,2-a] pyrimidin-4-ylidenamine from 2-(benzenesulfonyl)-3,3-bis (methylsulfanyl) acrylonitrile. J Med Chem. 2003 Nov 6;46(23):4834-7.
(E)-3-(Benzenesulfonyl)-2-(methylsulfanyl) pyrido [1,2-a] pyrimidin-4-ylidena mine (7) was found to be a potent and selective 5-HT (6) antagonist. A one-step synthesis of this compound is described. |
32(0,1,1,2) |