| ID | 36 |
|---|---|
| Name | glutathione S transferase |
| Synonyms | GST class alpha 2; Gst2; GST class alpha; GST class alpha member 2; GST gamma; GSTA 2; GSTA2; GSTA2 2… |
| ID | 183 |
|---|---|
| Name | lindane |
| CAS | (1α,2α,3β,4α,5α,6β)-1,2,3,4,5,6-hexachlorocyclohexane |
| PubMed | Abstract | RScore(About this table) |
|---|---|---|
| 1283138 | Joseph P, Shivanandappa T, Narasimhamurthy K, Krishnakumari MK: Effect of on hexachlorocyclohexane (HCH) toxicity in the rat. Gen Pharmacol. 1992 Nov;23(6):1159-64. 1. Technical hexachlorocyclohexane (HCH) depleted hepatic stores of in male albino rats to cause secondary deficiency. 2. Toxicity of HCH in rats is augmented by dietary -deficiency as evidenced by growth retardation, organ hypertrophies and alterations in the serum and liver levels of the marker enzymes of toxicity. 3. Supplementation of dietary to the rats either in adequate (2000 IU/kg diet) or in an excess but not hypervitaminotic level (10 (5) IU/kg diet) resulted in significant protection against the toxicity of HCH. 4. The activities of the hepatic xenobiotic metabolizing enzymes were generally low (with the exception of glutathione S-transferase) in the -deficient rats compared to those of the supplemented diet groups. 5. The results indicated that dietary influences the response of male albino rats to HCH toxicity possibly by modulating the activities of hepatic xenobiotic metabolizing enzymes. |
1(0,0,0,1) |