| 18317933 |
Wang MY, Nowicki D, Anderson G, Jensen J, West B: Liver protective effects of Morinda citrifolia (Noni). Plant Foods Hum Nutr. 2008 Jun;63(2):59-63. Epub 2008 Mar 4.
This study evaluated the protective effects of Noni fruit juice on acute liver injury induced by carbon tetrachloride (CCl (4)) in female Sprague-Dawley (SD) rats. Liver damage (micro-centrilobular necrosis) was observed in animals pretreated with 20% placebo (drinking water) + CCl (4). However, pretreatment with 20% Noni juice in drinking water + CCl (4) resulted in markedly decreased hepatotoxic lesions. Furthermore, serum alanine aminotransferase and aspartate aminotransferase levels were significantly lower in the Noni group than the placebo group. In a correlative time-dependent study, one dose of CCl (4) (0.25 mL/kg in corn oil, p.o.) in female SD rats, pretreated with 10% placebo for 12 days, caused sequential progressive hepatotoxic lesions over a 24 h period, while a protective effect from 10% Noni juice pretreatment was observed. These results suggest that Noni juice is effective in protecting the liver from extrinsic toxin exposure. |
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