| 17450508 |
Moresco RN, Sperotto RL, Bernardi AS, Cardoso RF, Gomes P: Effect of the aqueous extract of Syzygium cumini on carbon tetrachloride-induced hepatotoxicity in rats. J Nutr Biochem. 2006 Mar;17(3):177-82. Epub 2005 Aug 10.
The aim of this study was to evaluate the effect of the aqueous Syzygium cumini leaf extract, given either as a single dose or by 7 days of pretreatment, on hepatotoxicity induced by carbon tetrachloride in rats. Blood samples obtained after treatments were measured for aspartate aminotransferase (AST) and alanine aminotransferase (ALT). A significant increase in the AST and ALT activities occurred after carbon tetrachloride administration alone, which was significantly lowered by preadministration with the aqueous extract of Syzygium cumini, but not by a single dose. This suggests that the extract may be useful for liver protection but needs to be given over a significant period and prior to liver injury. |
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