| 17078107 |
Wu JB, Lin WL, Hsieh CC, Ho HY, Tsay HS, Lin WC: The hepatoprotective activity of kinsenoside from Anoectochilus formosanus. Phytother Res. 2007 Jan;21(1):58-61.
Carbon tetrachloride (CCl (4)) causes chronic hepatitis, featuring an increase in hepatic hydroxyproline, spleen weight and serum GPT levels and a decrease in plasma albumin levels. Crude extracts of fresh whole plants of Anoectochilus formosanus showed inhibition of chronic hepatitis induced by CCl (4) in mice. Bioactivity-guided fractionation and spectroscopic analysis revealed that kinsenoside was the most active compound. In an in vitro study, the LD (50) values for H (2) O (2)-induced cytotoxicity in BALB/c normal liver cells were significantly higher after kinsenoside pretreatment than after vehicle alone, further confirming that kinsenoside shows significant antihepatotoxic activity. |
6(0,0,1,1) |