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Shih TW, Hill DL: Metabolic activation of 1,2-dibromoethane by glutathione transferase and by microsomal mixed function oxidase: further evidence for formation of two reactive metabolites. Res Commun Chem Pathol Pharmacol. 1981 Sep;33(3):449-61.
In liver cytosolic preparations containing added glutathione, radioactivity from [14C] 1,2-dibromoethane becomes bound preferentially to added polycytidylic acid. When microsomes and NADPH are present, however, the radioactivity becomes bound selectively to microsomal proteins. |
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