| 16884807 |
Zweers ML, Engbers GH, Grijpma DW, Feijen J: Release of anti-restenosis drugs from poly (ethylene oxide)-poly (DL-lactic-co-glycolic acid) nanoparticles. J Control Release. 2006 Sep 12;114(3):317-24. Epub 2006 Jun 2.
Dexamethasone- or rapamycin-loaded nanoparticles based on poly (ethylene oxide) and poly (dl-lactic-co-glycolic acid) block copolymers (PEO-PLGA) were prepared without additional stabilizer using the salting-out method. A fast release of drug in PBS (pH 7.4) at 37 degrees C resulting in 100% release within 5 h was observed for both drugs. The rate of drug release was substantially reduced by treating the particles with gelatin or albumin after drug loading, resulting in a linear drug release in time. It was shown that the rate of drug release is related to the amount of protein associated with the nanoparticles. After gelatin treatment of drug-loaded nanoparticles, sustained release of dexamethasone for 17 days and of rapamycin for 50 days could be achieved. |
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