| 12901435 |
Koyama Y, Ito T, Matsumoto H, Tanioka A, Okuda T, Yamaura N, Aoyagi H, Niidome T: Novel poly (ethylene glycol) derivatives with carboxylic acid pendant groups: synthesis and their protection and enhancing effect on non-viral gene transfection systems. J Biomater Sci Polym Ed. 2003;14(6):515-31.
Novel carboxylic acid pendant-containing poly (ethylene glycol) (PEG) derivatives (PEG-Cs) were synthesized by the chemical modification of the carbon-carbon double-bond side chain of copoly (allyl glycidyl ether/ethylene oxide) (copoly (AGE/EO)). PEG-C showed a protecting ability for the DNA/polycation complex from the albumin-induced aggregation. It also expressed the enhanced efficiency on the polycation-mediated gene transfection on the cultured cells (up to 3-4-times higher), probably due to its disperse-stabilizing property and also the proton-sponge effect. |
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